Potentiometric Probes
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Includes topics from ratiometric imaging to dye toxicity with hopefully something to help experts and newcomers alike get the most from their voltage imaging experiments.
What We Do
Potentiometric Probes develops and supplies voltage-sensitive dyes (VSDs) for academic and pharmaceutical industry researchers. These fluorescent dyes are used to stain cells, tissues, and whole organs and allow electrical activity of the brain and heart to be studied optically using microscopes. Voltage-sensitive dyes are used in basic research, as well as for drug discovery and cardiac safety screening of developmental drugs.
Advantages of Ratiometric Voltage Imaging
In the video below, spontaneously beating human stem cell-derived cardiomyocytes stained with ElectroFluor630TM (aka Di-4-ANEQ(F)PTEA) allows ratiometric optical action potential recordings. The ratio of two excitation wavelengths boosts signals and removes artifacts due to non-uniform staining, bleaching, and the motion of these beating (contracting) human heart cells in a dish. Learn more on our Cardiac Research page.
What’s Next?
Potentiometric Probes is developing new VSD technology that promises to have a rapid response as well as high sensitivity for the highest resolution and most informative optical voltage recordings possible.
Our Products
Voltage-sensitive dyes such as Di-4-ANEPPS bind to cell membranes and translate voltage changes in cells to changes in fluorescence. You can view all of our classic, fluorinated, and long-wavelength dyes on our product page.
Voltage Sensitive Dye Research
