Membrane binding of voltage-sensitive dyes from Potentiometric Probes including Di-4-ANEPPS

Voltage Sensors from Potentiometric Probes

Voltage-sensitive dyes such as Di-4-ANEPPS bind to cell membranes and translate voltage changes in cells to changes in fluorescence.

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Voltage-sensitive dye recordings from dendritic spines, Corey Acker

Voltage-Sensitive Dyes for Neuroscience Research

Voltage-sensitive dyes are currently used to study diverse, fundamental questions in neuroscience research using a large variety of cell, tissue, and whole animal assays.

Neuro Research
Arrhythmia in live pig heart seen with voltage-sensitive dye, Peter Lee

Voltage-Sensitive Dyes for Cardiac Research

Voltage-sensitive dyes are currently used for cardiac research from single-cell to whole-heart applications.

Cardiac Research
Voltage-sensitive dyes like Di-4-ANEPPS for high throughput screening, cardiac toxicity.

Voltage-Sensitive Dyes for High Throughput Screening

Voltage-sensitive dyes are currently used for high throughput screening assays during drug development for efficacy and toxicology/cardiac safety assessments.

High Throughput Screening

Potentiometric Probes develops and supplies voltage-sensitive dyes (VSDs) for academic and pharmaceutical industry researchers. These fluorescent dyes are used to stain cells, tissues, and whole organs and allow electrical activity of the brain and heart to be studied optically using microscopes. Voltage-sensitive dyes are used in basic research, as well as for drug discovery and cardiac safety screening of developmental drugs.

Potentiometric Probes is developing new VSD technology that promises to have rapid response as well as high sensitivity for the highest resolution and most informative optical voltage recordings possible.